longiron.blogg.se - Dmg international

In its most recent list of pathogens that require new antibiotics, the World Health Organization (WHO) lists carbapenem-resistant Enterobacteriaceae (CRE) in its highest (critical) priority group 1. Among Enterobacteriaceae, multi-drug resistant (MDR) species pose one of the biggest public health challenges of our time. For instance, in 2013, the annual cost associated with non-typhoidal Salmonella infections alone was estimated at 3.67 billion dollars in the United States (United States Department of Agriculture). Our results suggest that DMG-mediated Ni-chelation could provide a novel approach to combat enteric pathogens, including recalcitrant multi-drug resistant strains.Įvery year, Enterobacteriaceae illnesses, including those by Escherichia, Klebsiella, Salmonella, Shigella and Yersinia species, cost billions of dollars in diarrheal illness treatment and lead to millions of human deaths. Typhimurium led to 40% and 60% survival, respectively, compared to 100% mortality of larvae infected with either pathogen, but without prior DMG administration. Inoculation of Galleria mellonella (wax moth) larvae with DMG prior to injection of either MDR K. Using Nuclear Magnetic Resonance, we were able to detect DMG in the livers of DMG-(orally) treated mice. Pathogen colonization numbers from livers and spleens of mice were 10- fold reduced by DMG treatment of the Salmonella-infected mice. Typhimurium led to a 50% survival rate, while 100% of infected mice in the no-DMG control group succumbed to salmonellosis. Oral delivery of nontoxic levels of DMG to mice previously inoculated with S. DMG inhibited activity of two Ni-containing enzymes, Salmonella hydrogenase and Klebsiella urease. Addition of DMG at millimolar levels has a bacteriostatic effect on some enteric pathogens, including multidrug resistant (MDR) strains of Salmonella Typhimurium and Klebsiella pneumoniae. Schottky diode switched from surface-mount SOT-23 package to through-hole DO-34.The nickel (Ni)-specific chelator dimethylglyoxime (DMG) has been used for many years to detect, quantitate or decrease Ni levels in various environments.

B vs C: almost exactly the same circuit, but the input filter no longer has an inductor, and many component values have been slightly changed.

A vs B: exactly the same circuit, but the board layout has been redone and small components now come in MicroMELF packages (vs 0603 imperial).

A1 vs A2 vs A3: one trace is laid out slightly differently at the bottom of the board.

DC CONV2 DMG (type D) visual component reference.

DC CONV DMG (type C) visual component reference.

DC CONV DMG (type B) visual component reference.

DC CONV DMG (type A) visual component reference.

DC CONV DMG (type A / type B) schematics.

Identify your board by looking at the following board version comparison photo. gbhwdb uses unofficial type A1/A2/A3/B/C/D designation, which is also used here. There are several versions of the regulator board, but the board label is not enough to distinguish the different versions. Original Game Boy LCD board (DMG-LCD-06) schematics Original Game Boy DC/DC power board (DC CONV DMG / DC CONV2 DMG)Ĭomponents were identified by desoldering and measuring everything on one board of each type (A/B/C/D). Traced AGS-CPU-11 board SVG Original Game Boy LCD board (DMG-LCD-06)Ĭomponents were identified by desoldering and measuring everything on a DMG-LCD-06 board. Game Boy Advance SP AGS-001 mainboard (AGS-CPU-11) schematics Note: there are several versions of Advance SP mainboards, and these schematics have accurate information only for AGS-CPU-11

Raw notes of MGB-ECPU-01 board components Game Boy Advance SP AGS-001 mainboard (AGS-CPU-11)Ĭomponents were identified by desoldering and measuring everything on a AGS-CPU-11 board. ArcadeTV.Ĭomponents were identified by desoldering and measuring everything on MGB-ECPU-01 and MGB-LCPU-01 boards. Traced based on high-res scans by Alex a.k.a. Game Boy Pocket mainboard (MGB-CPU-01, MGB-ECPU-01, MGB-LCPU-01, MGB-LCPU-02) MGB-xCPU/MGB-LCPU-02.jpg: assumed to be in public domain based on the readme.txt file.Licensed under Creative Commons Attribution 4.0 International.